MSU Researcher Seeking to Improve Treatments for Autoimmune Diseases

James Pestka, the Robert and Carol Deibel Family Endowed Professor at MSU.

According to the American Autoimmune Related Diseases Association, as many as 50 million Americans may be living with an autoimmune disorder. Many of these remain undiagnosed and, without intervention, can worsen over time. Given current treatment options, however, even those being actively managed can be met with complications.

Autoimmune diseases can affect individuals at any age and cause the body’s immune system to attack its own healthy tissues. While there are no known cures, most current management strategies involve symptom reduction through immunosuppressive medication, which can present its own challenges with harmful side effects.

Some of the most common autoimmune diseases are type-1 diabetes, lupus, psoriasis and rheumatoid arthritis.

James Pestka, a University Distinguished Professor at Michigan State University, has dedicated his career to understanding more about the causes of — and potential alternative treatments for — autoimmune diseases, particularly lupus.

“Autoimmune diseases such as lupus have a devastating effect on many individuals, and while there have been advancements in treatment, we still have substantial knowledge gaps,” Pestka said. “The goal of my research program is to understand how we can supplement — through actions like dietary changes — or even replace medications that, while effective, are currently either inaccessible to many people due to cost or present several adverse side effects.”

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Michigan State University AgBioResearch scientists discover dynamic solutions for food systems and the environment. More than 300 MSU faculty conduct leading-edge research on a variety of topics, from health and climate to agriculture and natural resources. Originally formed in 1888 as the Michigan Agricultural Experiment Station, MSU AgBioResearch oversees numerous on-campus research facilities, as well as 15 outlying centers throughout Michigan. To learn more, visit agbioresearch.msu.edu.