Inside the Great Healthcare Disruption: How AI, Big Tech and Breakthrough Drugs Are Rewriting American Medicine
Photo by Tima Miroshnichenko
WESTPORT, CT, Dec. 2025 — Dr. Marschall Runge’s The Great Healthcare Disruption examines how technological advances, policy changes and emerging business models are fundamentally transforming American healthcare. Drawing from his experience as former Executive Vice President for Medical Affairs at the University of Michigan and CEO of Michigan Medicine, Runge argues that healthcare stands at a revolutionary inflection point where multiple disruptive forces are reshaping every aspect of care delivery.
The book systematically analyzes major healthcare disruptors,
including retail medicine (Amazon, CVS, Walmart), emerging gene and mRNA therapies, artificial intelligence applications, new obesity drugs, virtual behavioral health platforms, and novel payment models. Rather than viewing these changes with alarm, Runge advocates embracing and directing disruption to address healthcare’s core challenges: high costs, limited access and uneven quality.
Throughout the text, Runge weaves together clinical insights, policy analysis, and personal observations to illuminate both the promise and perils ahead. He argues that successfully navigating this transformation requires:
• Reimagining primary care delivery through both virtual and retail channels
• Leveraging AI and automation to extend provider capabilities
• Making breakthrough therapies more affordable and accessible
• Building more resilient systems to handle future crises
• Shifting focus from treating illness to preventing disease
• Finding sustainable ways to pay for innovation
The book concludes with a call for proactive change,
arguing that passively responding to disruption is insufficient. Instead, healthcare leaders must actively shape how new technologies and business models evolve to ensure they advance core missions of expanding access, improving outcomes and controlling costs.
In an accessible and reader-friendly manner, The Great Healthcare Disruption offers a comprehensive roadmap for healthcare’s future while remaining grounded in practical realities. Runge’s balanced perspective — embracing innovation while acknowledging implementation challenges — makes this a valuable guide for healthcare leaders navigating unprecedented change.
The Great Healthcare Disruption: Big Tech, Bold Policy, and the Future of American Medicine
Publisher: Forbes Books
ISBN-13: 979-8887505909
Available from https://www.amazon.com/Great-
ABOUT DR. MARSCHALL RUNGE
Marschall Runge, MD, Ph.D., is the former CEO of Michigan Medicine and Dean of the University of Michigan Medical School, and a practicing cardiologist. During his tenure in these leadership roles, Dr. Runge implemented transformative change and positioned Michigan Medicine and the Medical School internationally for continued success.
He earned his doctorate in molecular biology at Vanderbilt University and his medical degree from Johns Hopkins School of Medicine, where he also completed a residency in internal medicine. He was a cardiology fellow at the Massachusetts General Hospital and has been a physician-scientist for his entire career.
Dr. Runge is the author of over 250 publications and holds five patents for novel approaches to health care. Dr. Runge is a gold medalist for the Global Book Awards. An avid thriller reader, he has experienced many you-can’t-make-this-up events that inform his fictional and nonfiction writing alike. In addition to The Great Healthcare Disruption, Dr. Runge is the author of the gripping medical thriller, Coded to Kill. For more information, please visit https://drmarschallrunge.com/.
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